Potassium Sodium Ratio Heart Failure

There are many health damaging effects of a poor potassium sodium ratio that occur even before blood pressure begins to rise. Last post we discussed how a poor potassium sodium ratio causes poor diastolic function of the heart even before blood pressure rises. If it goes on long enough, the poor ratio can lead to scarring in the heart. Finally, this scarring will cause the heart to fail. It becomes too weak to pump blood.

Heart Muscle Cell

At an early stage, this poor diastolic function can be easily corrected. Simply getting a favorable potassium sodium ratio returns function to normal. But if not corrected, over time, this dysfunction becomes more difficult to reverse. Areas of fibrosis (scarring) begin to show up in the heart when examined under the microscope. A series of experiments examined the subcellular mechanism that leads to the scarring in the heart in heart failure.

Subcellular Look At Heart Failure

The researchers who did this series of experiments recently reviewed their studies in an article (1). In this case, animals experimentally subjected to high salt intake (potassium sodium ratio of 0.53), and high amounts of aldosterone, developed small foci of necrosis (dead heart cells) in the heart ventricle within 4 weeks. Subsequently these areas of dead heart cells form small areas of scar tissue. But in contrast to the scarring from a heart attack, the areas of scarring are much smaller.

Over time this scarring takes up an increasing percentage of the heart. When the percentage is too much, the remaining heart muscle cells cannot pump blood strongly enough. This is known as heart failure.

How A Poor Potassium Sodium Ratio Damages Heart Cells

Subsequently, the researchers studied the mechanism for this at the subcellular level. To summarize their findings, an increased salt intake leads to a shift in the calcium load inside the heart cell. Calcium builds up in the mitochondria, causing the mitochondria to function poorly. Because the mitochondria are the power plants of the cell, all the functions performed by the cell cannot keep up. And the cell dies.

Additionally, the researchers found an association of this calcium buildup with an increase in free radicals (ROS). Free radicals interfere with the movement of electrons needed by the mitochondria for their work.

A Poor Ratio Messes Up Pores

Ultimately two pores in the mitochondrial membrane begin to function poorly. These are the mPTP pore and the BK(Ca) pore. The mPTP pore lets in too much fluid. The mitochondria swell and can no longer function.

The BK(Ca) pore affects the mPTP pore. When the BK(Ca) pore can let potassium into the mitochondria, it can keep the mPTP pore from opening too much. But the BK(Ca) pore opens and closes based on the calcium concentration. Because there is too much calcium in the mitochondria, the BK(Ca) pore cannot hold back the mPTP pore. The mitochondria swell, and then the cell swells and bursts.

Cell Burst Means Scar

When a cell swells and bursts, the cell contents that are released attract inflammatory cells. As a result, these inflammatory cells set off a chain reaction that results in scar tissue. These small areas of scarring (fibrosis) eventually get larger and larger. Finally, when the scarring is too much, the heart fails.

Thus, hypertension can lead to irreversible damage. This publication demonstrates one example of how this can happen. Similarly, these types of subcellular damage occur to other cells in the body also. This particular example is one of the best detailed series of experiments at showing how this damage happens.

It's Not Just The Pressure

With these studies we begin to get an excellent understanding of how the potassium sodium balance affects the workings inside the cell. The effects of a poor potassium sodium ratio are not limited to simply increasing blood pressure. The effects occur throughout the body, affecting every cell.

As demonstrated in the ventricle of the heart, it is not just the mechanical effects of the pressure in the arteries that is important. The mechanical elevation of blood pressure is just an end result of many disrupted cellular functions. Unless corrected in a timely manner, the cellular damage leads to irreversible changes.

In some earlier experiments the researchers had one set of control animals get a potassium sodium ratio of 1.33. These animals did not develop the scarring in the heart.

How You Can Prevent Heart Failure

If you, like most Americans, have been on a high sodium, low potassium diet for a long time, you can stop these changes. You can even possibly reverse some of them. If you are young, you can prevent them with a high potassium, low sodium diet.

Tables Of High Potassium Foods

To find tables with the potassium and sodium content of foods, use the “Links to Food Potassium Tables” tab at the top of this page. Then click on a table you are interested in.

1. Intracellular calcium overloading and oxidative stress in cardiomyocyte necrosis via a mitochondriocentric signal-transducer-effector pathway. Mazen Shaheen, MD, Yaser Cheema, MD, Atta U Shahbaz, MD, Syamal K Bhattacharya, PhD, and Karl T Weber, MD. Exp Clin Cardiol. 2011 Winter; 16(4): 109–115.

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